Selected Publications
Publications in the past four years out of 51 total peer-reviewed manuscripts.
2022
Increased eHSP70-to-iHSP70 ratio disrupts vascular responses to calcium and activates the TLR4-MD2 complex in type 1 diabetes. de Oliveira AA*, Priviero F, Webb RC, Nunes KP. Life Sciences; 310:121079, 2022. DOI: 10.1016/j.lfs.2022.121079
Drugs from animal venoms: Overcoming the challenges to treat erectile dysfunction. De Lima ME, Nunes KP. Venoms and Toxins; vol 2, issue 2, 2022. DOI: 10.2174/2666121702666220425111433
Connecting aortic stiffness to vascular contraction: Does sex matter? de Oliveira AA*, Priviero F, Delgado A*, Pengfei D, Mendoza VO*, Gu L, Webb RC, Nunes KP. International Journal of Molecular Sciences; 23(19):11314, 2022. DOI: 10.3390/ijms23191131.
New insights into the role and therapeutic potential of HSP70 in diabetes. de Oliveira AA*, Mendoza VO*, Rastogi S*, Nunes KP. Pharmacological Research, 178:106173, 2022. DOI: 10.1016/j.phrs.2022.106173
Age-related decline in vascular responses to phenylephrine is associated with reduced levels of HSP70. de Oliveira AA*, Mendoza VO, Priviero F, Webb RC, Nunes KP. Biomolecules; 12(8):1125, 2022. DOI: 10.3390/biom12081125
This original article was selected as “Editor Choice”.
From the PnTx2-6 toxin to the PnPP-19 Engineered Peptide: Therapeutic Potential in Erectile Dysfunction, Nociception, and Glaucoma. da Silva CN, Nunes KP, Dourado LFN, Vieira TO, Mariano XM, Cunha Junior ADS, de Lima ME. Front Mol Biosci,11;9:831823, 2022. DOI: 10.3389/fmolb.2022.831823
2021
Impaired HSP70 expression in the aorta of female rats: a novel insight into sex-specific differences in vascular function. de Oliveira AA*, Priviero F, Webb RC, Nunes KP. Frontiers in Physiology, 12:517, 2021. DOI: 10.3389/fphys.2021.666696
COVID-19 and ROS Storm: What is the Forecast for hypertension. de Oliveira AA, Priviero F, Lima VV, Webb RC, Nunes KP. Am J Hypertension, 9;34(8):779-782, 2021. DOI: 10.1093/ajh/hpab085.
The synthetic peptide PnPP-19 potentiates erectile function via nNOS- and iNOS. CN da Silva, KP Nunes, FM Almeida, GC Silva, PS Cunha, TF Diniz, LM Maia, VS Lemos; DA Gomes, ME de Lima. Nitric Oxide, 113-114: 23-30, 2021. DOI: doi.org/10.1016/j.niox.2021.04.007
New insights into RhoA/Rho-kinase signaling: a key regulator of vascular contraction. Nunes KP, Webb RC. Small GTPases. 12(5-6):458-469, 2021. DOI: 10.1080/21541248.2020.1822721
Crosstalk of TLR4, vascular NADPH oxidase, and COVID-19 in diabetes: What are the potential implications? de Oliveira AA* & Nunes KP. Vascular Pharmacology; 26:106879, 2021. DOI: 10.1016/j.vph.2021.106879
Medical Xpress highlighted this topical review.
2020
Dissecting the interaction between HSP70 and vascular contraction: role of Ca2+ handling mechanisms. de Oliveira AA, Priviero F, Tostes R, Webb RC, Nunes K. Scientific Reports, 11:1420, 2020. DOI: 10.1038/s41598-021-80966-6
Hypertension and erectile dysfunction: breaking down the challenges. de Oliveira AA*, Nunes KP. American Journal of Hypertension. 34(2):134-142, 2020. DOI: 10.1093/ajh/hpaa143
This article was written to fulfill an invitation from Dr. Ernesto Schiffrin, Editor-in-Chief of the AJH.
Blockade of TLR4-MD2 complex lowers blood pressure and improves vascular function in a murine model of type 1 diabetes. AA de Oliveira*, J Faustino*, RC Webb, KP Nunes. Scientific Reports 10, 12032, 2020. DOI: 10.1038/s41598-020-68919-x
An additional physiological role for HSP70: Assistance of vascular reactivity. AA de Oliveira* & KP Nunes. Life Sciences, 117986, 2020. DOI: 10.1016/j.lfs.2020.117986
Angiotensin (1-7) Inhibits Ang II-mediated ERK1/2 Activation by Stimulating MKP-1 Activation in Vascular Smooth Muscle Cells. A Sousa-Lopes, R Alves de Freitas, FS Carneiro, KP Nunes, et al. International Journal of Molecular and Cellular Medicine (IJMCM), 9 (1), 50-61, 2020. DOI: 10.22088/IJMCM.BUMS.9.1.50
Blockade of Toll-like receptor 4 (TLR4) reduces oxidative stress and restores phospho-ERK1/2 levels in Leydig cells exposed to high glucose. T Karpova, AA de Oliveira*, H Naas*, F Priviero, KP Nunes. Life Sciences, 117365, 2020. DOI: 10.1016/j.lfs.2020.117365
2019
Toll-like receptor 4 (TLR4) as a possible pathological mechanism in hyperglycemia-associated testicular dysfunction. H Naas*, AA de Oliveira*, T Karpova, KP Nunes. Medical Hypotheses, 127, 116-119, 2019. DOI: 10.1016/j.mehy.2019.04.010
Toll-like receptor 4 and blood pressure: Lessons from animal studies. KP Nunes, AA de Oliveira*, VV Lima, RC Webb. Frontiers in Physiology, 655, 2019. DOI: 10.3389/fphys.2019.00655
Unveiling the interplay between the TLR4/MD2 complex and HSP70 in the human cardiovascular system: a computational approach. AA de Oliveira*, J Faustino*, ME de Lima, R Menezes, KP Nunes. International Journal of Molecular Sciences, 20 (13), 3121, 2019. DOI: 10.3390/ijms20133121
PnPP-19 Peptide Restores Erectile Function in Hypertensive and Diabetic Animals Through Intravenous and Topical Administration. CN da Silva, KP Nunes, FDM Almeida, FLS Costa, PV Borges, P Lacativa, et al. The Journal of Sexual Medicine, 16 (3), 365-374, 2019. DOI: 10.1016/j.jsxm.2019.01.004
Pattern recognition receptors as potential therapeutic targets in metabolic syndrome: From bench to bedside. AA de Oliveira*, D Davis*, KP Nunes. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 13 (2), 1117-1122., 2019. DOI: 10.1016/j.dsx.2019.01.012
SELECTED Book Chapters:
- De Lima ME, Figueiredo SG, Matavel A, Nunes KP, da Silva NC, Almeida FM, Diniz MRV, Cordeiro MN, Stankiewicz M and Beirao PSL.(2015). Phoneutria nigriventer Venom and Toxins: A Review. In: Spider Venoms. Edited by Springer Science. DOI: 10.1007/978-94-007-6646-4_6_1
- Kenia P. Nunes and R. Clinton Webb. (2011) Mechanisms in Erectile Function and Dysfunction: An Overview. In: Erectile Dysfunction - Disease-Associated Mechanisms and Novel Insights into Therapy. Chapter 01, Edited by In Tech Book. DOI: 10.5772/39088
- Nunes KP, Cardoso, F.L., Cardoso Jr, H.C., Pimenta, A.M.C., De Lima, M.E. (2009) Animal toxins as potential pharmacological tools for the treatment of erectile dysfunction. In: Animal toxins: State of the art Perspectives in health and biotechnology, vol. 1 (De Lima, M. E., Pimenta, A.M.C., Martin-Eauclaire, M.F., Zingali, R. and Rochat, H., ed), pp 314-322 Belo Horizonte: UFMG Editora.
